Search results for " hypoimmunogenicity"

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Wharton’s Jelly Mesenchymal Stem Cells as Candidates for Beta Cells Regeneration: Extending the Differentiative and Immunomodulatory Benefits of Adul…

2010

Mesenchymal stem cells (MSC) are uniquely capable of crossing germinative layers borders (i.e. are able to differentiate towards ectoderm-, mesoderm- and endoderm-derived cytotypes) and are viewed as promising cells for regenerative medicine approaches in several diseases. Type I diabetes therapy should potentially benefit from such differentiated cells: the search for alternatives to organ/islet transplantation strategies via stem cells differentiation is an ongoing task, significant goals having been achieved in most experimental settings (e.g. insulin production and euglycaemia restoration), though caution is still needed to ensure safe and durable effects in vivo. MSC are obtainable in …

Graft RejectionCancer ResearchCellular differentiationCell Culture TechniquesClinical uses of mesenchymal stem cellsBiologyMesenchymal Stem Cell TransplantationRegenerative medicineUmbilical CordImmunomodulationMesenchymal stem cells Umbilical cord Wharton’s jelly Type 1 diabetes Beta cells Differentiation markers Pancreas development Inflammation Immune modulation HypoimmunogenicityInsulin-Secreting CellsWharton's jellyAnimalsHumansRegenerationEmbryonic Stem CellsSettore BIO/16 - Anatomia UmanaRegeneration (biology)Mesenchymal stem cellCell DifferentiationMesenchymal Stem CellsCell BiologyAntigens DifferentiationTransplantationAdult Stem CellsDiabetes Mellitus Type 1Adipose TissueImmunologyCancer researchCord Blood Stem Cell TransplantationStem cellStem Cell Reviews and Reports
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Recent patents and advances on isolation and cellular therapy applications of mesenchymal stem cells from human umbilical cord Wharton's jelly

2011

In recent years, important advances were made to clarify the biology and potential use of mesenchymal stem cells (MSC) in the therapy of a number of disorders. MSC are present in a number of tissues, ranging from adult bone marrow, to several adult organs, adipose tissue and, in the last years, the fetal-associated (also named as extraembryonic) tissues (e.g. placenta, amniotic membrane, umbilical cord). In particular, research on cells derived from mature umbilical cord, a tissue which is still discarded at birth, showed that mesenchymal stem cells can be successfully isolated from the Wharton’s jelly (WJ), the main constituent of this organ. This review will take in to account the patents…

Isolation (health care)business.industrySettore BIO/16 - Anatomia UmanaMesenchymal stem cellCell BiologyUmbilical cordCell biologyCell therapymedicine.anatomical_structureDevelopmental NeuroscienceWharton's jellyMedicinebusinessCellular therapy human umbilical cord hypoimmunogenicity immune regulation isolation and differentiation mesenchymal stem cells stem cells patents Wharton’s jellyDevelopmental Biology
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